SrasV1, Main, Exploration, bibRecord, 003B36

SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus

Identifieur interne : 003B36 ( Main/Exploration ); précédent : 003B35; suivant : 003B37

SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus

Auteurs : Masahiro Kitabatake [Japon] ; Shingo Inoue [Japon] ; Fumihiko Yasui [Japon] ; Shoji Yokochi [Japon] ; Masaaki Arai [Japon] ; Kouichi Morita [Japon] ; Hisatoshi Shida [Japon] ; Minoru Kidokoro [Japon] ; Fukashi Murai [Japon] ; Mai Quynh Le [Viêt Nam] ; Kyosuke Mizuno [Japon] ; Kouji Matsushima [Japon] ; Michinori Kohara [Japon]

Source :

Vaccine [ 0264-410X ] ; 2007.

RBID : Pascal:07-0076944

Descripteurs français

Pascal (Inist)
- Virus vaccine, Lapin, Virus syndrome respiratoire aigu sévère, Protéine recombinante, Virus recombinant, Anticorps neutralisant, Immunisation, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Lapin.

English descriptors

KwdEn :
- Immunization, Neutralizing antibody, Rabbit, Recombinant protein, Recombinant virus, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Vaccinia virus.

Abstract

A vaccine for severe acute respiratory syndrome (SARS) is being intensively pursued against its re-emergence. We generated a SARS coronavirus (SARS-CoV) spike protein-expressing recombinant vaccinia virus (RVV-S) using highly attenuated strain LC16m8. Intradermal administration of RVV-S into rabbits induced neutralizing (NT) antibodies against SARS-CoV 1 week after administration and the NT titer reached 1:1000 after boost immunization with RVV-S. Significantly, NT antibodies against SARS-CoV were induced by administration of RVV-S to rabbits that had been pre-immunized with LC16m8. RVV-S can induce NT antibodies against SARS-CoV despite the presence of NT antibodies against VV. These results suggest that RVV-S may be a powerful SARS vaccine, including in patients previously immunized with the smallpox vaccine.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Kohara, Michinori" sort="Kohara, Michinori" uniqKey="Kohara M" first="Michinori" last="Kohara">Michinori Kohara</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus</title>
<author><name sortKey="Kitabatake, Masahiro" sort="Kitabatake, Masahiro" uniqKey="Kitabatake M" first="Masahiro" last="Kitabatake">Masahiro Kitabatake</name>
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<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1, Hongo</s1>
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<author><name sortKey="Inoue, Shingo" sort="Inoue, Shingo" uniqKey="Inoue S" first="Shingo" last="Inoue">Shingo Inoue</name>
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<author><name sortKey="Yasui, Fumihiko" sort="Yasui, Fumihiko" uniqKey="Yasui F" first="Fumihiko" last="Yasui">Fumihiko Yasui</name>
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<author><name sortKey="Yokochi, Shoji" sort="Yokochi, Shoji" uniqKey="Yokochi S" first="Shoji" last="Yokochi">Shoji Yokochi</name>
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<author><name sortKey="Arai, Masaaki" sort="Arai, Masaaki" uniqKey="Arai M" first="Masaaki" last="Arai">Masaaki Arai</name>
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<author><name sortKey="Morita, Kouichi" sort="Morita, Kouichi" uniqKey="Morita K" first="Kouichi" last="Morita">Kouichi Morita</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4</s1>
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<author><name sortKey="Shida, Hisatoshi" sort="Shida, Hisatoshi" uniqKey="Shida H" first="Hisatoshi" last="Shida">Hisatoshi Shida</name>
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<author><name sortKey="Kidokoro, Minoru" sort="Kidokoro, Minoru" uniqKey="Kidokoro M" first="Minoru" last="Kidokoro">Minoru Kidokoro</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Third Department of Virology, National Institute of Infectious Diseases, 4-7-1</s1>
<s2>Gakuen, Musashimurayama 208-0011</s2>
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<wicri:noRegion>Gakuen, Musashimurayama 208-0011</wicri:noRegion>
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<author><name sortKey="Murai, Fukashi" sort="Murai, Fukashi" uniqKey="Murai F" first="Fukashi" last="Murai">Fukashi Murai</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Post Genome Institute Co., Ltd., 3-38-1, Hongo</s1>
<s2>Bunkyo-ku, Tokyo 113-0033</s2>
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<sZ>4 aut.</sZ>
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<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
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<author><name sortKey="Quynh Le, Mai" sort="Quynh Le, Mai" uniqKey="Quynh Le M" first="Mai" last="Quynh Le">Mai Quynh Le</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Virology, National Institute of Hygiene and Epidemiology</s1>
<s2>Hanoi</s2>
<s3>VNM</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Viêt Nam</country>
<wicri:noRegion>Hanoi</wicri:noRegion>
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<author><name sortKey="Mizuno, Kyosuke" sort="Mizuno, Kyosuke" uniqKey="Mizuno K" first="Kyosuke" last="Mizuno">Kyosuke Mizuno</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Chemo-Sero-Therapeutic Research Institute, 1-6-1</s1>
<s2>Okubo, Kumamoto 860-8568</s2>
<s3>JPN</s3>
<sZ>11 aut.</sZ>
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<wicri:noRegion>Okubo, Kumamoto 860-8568</wicri:noRegion>
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</author>
<author><name sortKey="Matsushima, Kouji" sort="Matsushima, Kouji" uniqKey="Matsushima K" first="Kouji" last="Matsushima">Kouji Matsushima</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1, Hongo</s1>
<s2>Bunkyo-ku, Tokyo 113-0033</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
<orgName type="university">Université de Tokyo</orgName>
<placeName><settlement type="city">Tokyo</settlement>
<region type="province">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kohara, Michinori" sort="Kohara, Michinori" uniqKey="Kohara M" first="Michinori" last="Kohara">Michinori Kohara</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome</s1>
<s2>Bunkyo-ku, Tokyo 113-8613</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Immunization</term>
<term>Neutralizing antibody</term>
<term>Rabbit</term>
<term>Recombinant protein</term>
<term>Recombinant virus</term>
<term>Severe acute respiratory syndrome</term>
<term>Severe acute respiratory syndrome virus</term>
<term>Vaccinia virus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus vaccine</term>
<term>Lapin</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>Protéine recombinante</term>
<term>Virus recombinant</term>
<term>Anticorps neutralisant</term>
<term>Immunisation</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Lapin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A vaccine for severe acute respiratory syndrome (SARS) is being intensively pursued against its re-emergence. We generated a SARS coronavirus (SARS-CoV) spike protein-expressing recombinant vaccinia virus (RVV-S) using highly attenuated strain LC16m8. Intradermal administration of RVV-S into rabbits induced neutralizing (NT) antibodies against SARS-CoV 1 week after administration and the NT titer reached 1:1000 after boost immunization with RVV-S. Significantly, NT antibodies against SARS-CoV were induced by administration of RVV-S to rabbits that had been pre-immunized with LC16m8. RVV-S can induce NT antibodies against SARS-CoV despite the presence of NT antibodies against VV. These results suggest that RVV-S may be a powerful SARS vaccine, including in patients previously immunized with the smallpox vaccine.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
<li>Viêt Nam</li>
</country>
<region><li>Région de Kantō</li>
</region>
<settlement><li>Tokyo</li>
</settlement>
<orgName><li>Université de Tokyo</li>
</orgName>
</list>
<tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Kitabatake, Masahiro" sort="Kitabatake, Masahiro" uniqKey="Kitabatake M" first="Masahiro" last="Kitabatake">Masahiro Kitabatake</name>
</region>
<name sortKey="Arai, Masaaki" sort="Arai, Masaaki" uniqKey="Arai M" first="Masaaki" last="Arai">Masaaki Arai</name>
<name sortKey="Arai, Masaaki" sort="Arai, Masaaki" uniqKey="Arai M" first="Masaaki" last="Arai">Masaaki Arai</name>
<name sortKey="Inoue, Shingo" sort="Inoue, Shingo" uniqKey="Inoue S" first="Shingo" last="Inoue">Shingo Inoue</name>
<name sortKey="Kidokoro, Minoru" sort="Kidokoro, Minoru" uniqKey="Kidokoro M" first="Minoru" last="Kidokoro">Minoru Kidokoro</name>
<name sortKey="Kitabatake, Masahiro" sort="Kitabatake, Masahiro" uniqKey="Kitabatake M" first="Masahiro" last="Kitabatake">Masahiro Kitabatake</name>
<name sortKey="Kohara, Michinori" sort="Kohara, Michinori" uniqKey="Kohara M" first="Michinori" last="Kohara">Michinori Kohara</name>
<name sortKey="Matsushima, Kouji" sort="Matsushima, Kouji" uniqKey="Matsushima K" first="Kouji" last="Matsushima">Kouji Matsushima</name>
<name sortKey="Mizuno, Kyosuke" sort="Mizuno, Kyosuke" uniqKey="Mizuno K" first="Kyosuke" last="Mizuno">Kyosuke Mizuno</name>
<name sortKey="Morita, Kouichi" sort="Morita, Kouichi" uniqKey="Morita K" first="Kouichi" last="Morita">Kouichi Morita</name>
<name sortKey="Murai, Fukashi" sort="Murai, Fukashi" uniqKey="Murai F" first="Fukashi" last="Murai">Fukashi Murai</name>
<name sortKey="Shida, Hisatoshi" sort="Shida, Hisatoshi" uniqKey="Shida H" first="Hisatoshi" last="Shida">Hisatoshi Shida</name>
<name sortKey="Yasui, Fumihiko" sort="Yasui, Fumihiko" uniqKey="Yasui F" first="Fumihiko" last="Yasui">Fumihiko Yasui</name>
<name sortKey="Yokochi, Shoji" sort="Yokochi, Shoji" uniqKey="Yokochi S" first="Shoji" last="Yokochi">Shoji Yokochi</name>
<name sortKey="Yokochi, Shoji" sort="Yokochi, Shoji" uniqKey="Yokochi S" first="Shoji" last="Yokochi">Shoji Yokochi</name>
</country>
<country name="Viêt Nam"><noRegion><name sortKey="Quynh Le, Mai" sort="Quynh Le, Mai" uniqKey="Quynh Le M" first="Mai" last="Quynh Le">Mai Quynh Le</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus

SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus

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